There is no Blues sound. Blues isn't a timbre.
You can play over a 12-bar with anything you like. Any guitar, any effects (if you use any) through any amp. That's what makes playing Blues appealing.
I cringe when I read or hear something about a Blues Tone/Sound. That's the reason I didn't buy a BOSS Blues Driver for the longest time, I thought it was a stupid name but actually, it is a really good pedal. And if ever there was a Blues Tone, it would probably sound a lot like an acoustic guitar since Blues was around a lot longer than the electric guitar.
Anyone who insists on certain guitars/gear gear for a "blues tone" is an idiot and should probably worry more about the notes than the tone.
Side note: My Favourite Amp
Oddly enough, it's not an amp, it's my SansAmp. If I play a song off one of my CDs to someone, I do get the odd compliment on my guitar sound. That sound is basically a BOSS DS-1 into a SansAmp TRI-A.C. The key to a SansAmp, at least for distortion pedals, is treat it as if it was a clean amp: no gain and master volume all they way up. And if I want it a little more Fender-y, I use the BOSS Fender Reverb pedal since it changes the tone a bit.
Here's what a Fender Baja Telecaster into a DS-1 and then into a SansAmp sounds like: https://youtu.be/QtnsAumB1y0